Metrics details. The medical records of patients diagnosed with basal cell carcinoma BCC and squamous cell carcinoma SCC in Hatay Antakya pathology laboratory between January and September were retrospectively included in the study. A total of tumors in NMSC cases were examined.
Solitary tumors were seen in Mean age of the patients was BCC was observed in 96 Mean diameter of all types of solitary and multiple tumors was 7. Nodular subtype focal cystic changes were observed in 49 All tumors solitary and multiple were seen on the face Well differentiated SCCs were detected in 20 cases Epidemiologic and histopathological investigations, routine skin scanning performed on the elderly population and dermatological examination will help to improve efficient health applications.
Non-melanoma skin cancers NMSCs are frequent in the United States with an estimated incidence of approximately two million cases per year[ 1 ]. NMSC caused 75, deaths between and [ 2 ].
In summer the climate is hot and arid, and in winters it is mild and rainy characteristic Mediterranean climate. Average temperatures are; The aim of the present study was to clarify the clinicopathologic features and morphological characteristics of NMSCs diagnosed in skin biopsies in Hatay, where ultraviolet exposure might be higher than in other regions of Turkey.
Other rarely seen types mentioned in the literature were not observed[ 3 , 4 ]. SCCs were categorized as grade 1 well differentiated tumors , 2 moderately differentiated tumors , 3 poorly differentiated tumors , and 4 anaplastic or undifferentiated tumors , based on the classification of the College of American Pathologists CAP and the TNM Classification of Malignant Tumours International Union Against Cancer [ 5 ]. NMSCs were seen on the face frontal, temporal, orbital, zygomatic, nasal, infraorbital, parotid, oral, buccal, mental regions , scalp, ear, neck, trunk, and extremities[ 6 ].
The t -test was used for comparing averages, the chi-test was used for comparing dispersion of two groups, and the Kruskal-Wallis-H test was used for comparing dispersion of multi-groups.
WHO classification of tumours of the central nervous system
All differences associated with a chance probability of 0. The median age detected in men for BCC was Distribution of cases among age groups were as follows: 20 to 40 years, 2. Median age of the cases with multiple tumors was Among 72 men SCCs were detected in 19 men Male or female dominancy was not observed among cases with multiple tumors. Most Mean diameters of all solitary and multiple tumors were 7.
WHO Classification of Tumours, 3rd Edition, Volume 6
Nodular solid subtype focal cystic changes were observed in 49 Predominantly nodular subtype was detected among mixed types. Focal pigmentations were detected in Well-differentiated grade 1 SCCs were detected in 20 cases All multiple SCCs were moderately differentiated. In our study, grade 3 poorly differentiated and 4 anaplastic or undifferentiated tumors were not detected. In our study, SCCs were multiple in two patients face, 1; ear, 1; scalp, 1; extremity, 1.
When relations between BCC subtypes and anatomic localizations were investigated, nodular subtypes were seen on the face Nodular solid types, consisting of a nodular nest of basal cell types which have peripheral palisading of lesional cell nuclei, a specialized stroma, tumor necrosis and focal cystic changes, were seen. In certain cases, particular nodular subtypes with one or more than one cystic space of different size and shape or cystic degenerations were observed.
Mixed subtypes were seen on the face Adenoid subtypes were seen on the face except in one patient. Adenoid type was characterized as nodular solid type, with mucoid appearance in tubular stroma, and gland-like structures pseudoglandular appearance. Infiltrative subtypes were seen on the face Histological features consisted of cord-like, elongated strands of basaloid cells infiltrating between collagen bundles, and palisading of the peripheral cells.
IARC Publications Website - Pathology and Genetics of Skin Tumours
Some cases, especially with nodular subtypes, had melanophages in the stroma and melanocytes within tumor islands which had melanin granules in dark-staining cytoplasm showed pigmentations. Along with mixed types in six patients and in patients with pure superficial multifocal types, on epidermal surface, ulcerations, and from epidermis to dermis buds and irregular proliferations, tumors which generate clefting between dermal layers, superficial type that had pigmentation on its center and melanin pigments on solid tumor nests were observed.
Nodular subtypes was observed in all multiple BCCs nodular; pure type, 6; mixed type, 1; adenoid,1; mixed, 1; micronodular, 1. SCCs were detected on the face Well differentiated SCC grade 1 is a tumor which consists of irregular masses of epidermal cells which show decreased dermal proliferation. Moderately differentiated SCCs were seen on the face Moderately differentiated grade 2 squamous cell carcinoma, nuclear and cytoplasmic pleomorphisms, keratin formation, horn cyst, and individually scattered keratinized cells were seen predominantly.
Morphological subtypes of basal cell carcinomas BCCs and their anatomic locations. Arch Dermatol ; Spiradenocylindromas of the skin: Tumors with morphological features of spiradenoma and cylindroma in the same lesion: Report of 12 cases. Pathol Int ; Spiradenocylindroma: An uncommon morphologic entity. Int J Dermatol ; Benign tumours with apocrine and eccrine differentiation. Fine needle aspiration cytology of dermal cylindroma. J Cytol ; Brooke-Spiegler syndrome. Dermatol Online J ; Spiradenocylindroma: Rapid increase in size attributed to hemorrhage.
Histopathology of cutaneous squamous cell carcinoma and its variants.
Pathology and Genetics of Skin Tumours
Stadler R and C Hartig. Epidermale Tumoren. Histopathologic der Haut, ed. Kerl, Cerroni, Wolff. Murphy G. Nonmelanocytic tumors of the skin.
- Services on Demand!
- Personality and Work: Reconsidering the Role of Personality in Organizations.
- Tumor Neurosurgery: Principles and Practice!
- Plays 1!
- Wisdom Hunter?
- WHO Classification of Skin Tumours.
- epathologies Observation.
Atlas of tumour pathology, ed. Grimwood RE et al. Proliferating cells of human basal cell carcinoma are located on the periphery of tumor nodules. Takata M and T Saida.
Early cancers of the skin: clinical, histopathological and molecular characteristics. Weedon D.
http://clublavoute.ca/rymac-pagina-conocer-gente.php Rongioletti F and BR Smoller. Unusual histological variants of cutaneous malignant melanoma with some clinical and possible prognostic correlations. Vogt T et al. Bullous malignant melanoma: an unusual differential diagnosis of a hemorrhagic friction blister. Banerjee SS et al. Diagnostic lessons of mucosal melanoma with osteocartilaginous differentiation.
Moreno A et al. Osteoid and bone formation in desmoplastic malignant melanoma. Desmoplastic malignant melanoma: a clinicopathological study of 25 cases. Desmoplastic melanoma: patterns of recurrence. Reed RJ. Minimal deviation melanoma. Borderline and intermediate melanocytic neoplasia. Childhood melanoma: update and treatment. Personalised recommendations.